Keep track of Intently (1)darunavir will improve the degree or effect of sildenafil by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
itraconazole will raise the stage or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Intently. Not advisable throughout and a couple of weeks just after itraconazole therapy when sildenafil is utilized for pulmonary arterial hypertension.
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Observe Intently (one)labetalol boosts effects of sildenafil by additive vasodilation. Use Caution/Observe. Sildenafil has systemic vasodilatory Attributes and should more reduced blood pressure in individuals getting antihypertensive prescription drugs.
It's not acknowledged if sildenafil or its metabolites are excreted in human breast milk. Simply because lots of medicines are excreted in human milk, warning need to be exercised when sildenafil citrate is administered to the nursing woman.
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armodafinil will reduce the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
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rifapentine will decrease the extent or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. check here Use Warning/Monitor. Potent CYP3A4 inducers are anticipated to bring about sizeable decreases in sildenafil plasma amounts
sotalol increases effects of sildenafil by additive vasodilation. Use Caution/Monitor. Sildenafil has systemic vasodilatory Qualities and may more decrease blood pressure level in individuals taking antihypertensive medicines.
Stiripentol is usually a CYP3A4 inhibitor and inducer. Observe CYP3A4 substrates coadministered with stiripentol for increased or reduced effects. CYP3A4 substrates may well have to have dosage adjustment.
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grapefruit will increase the amount or effect of sildenafil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.